Single-molecule force spectroscopy of supramolecular heterodimeric capsules.

Tetraurea calix[4]arenes with sulfur functions: synthesis, dimerization to capsules, and self-assembly on gold.

Various calix[4]arene derivatives, fixed in the cone conformation by decylether groups and functionalized at their wide rim by urea residues, were synthesized. In two compounds (,) sulfur functions were attached to the urea groups via different spacers in order to allow binding to metal surfaces. While they exist as single molecules in polar solvents, tetraurea calix[4]arenes of this type () co...

Formation of heterodimeric resorcin[4]arene capsules on surfaces: an X-ray photoelectron spectroscopy investigation.

Mechanical stability of bivalent transition metal complexes analyzed by single-molecule force spectroscopy

Multivalent biomolecular interactions allow for a balanced interplay of mechanical stability and malleability, and nature makes widely use of it. For instance, systems of similar thermal stability may have very different rupture forces. Thus it is of paramount interest to study and understand the mechanical properties of multivalent systems through well-characterized model systems. We analyzed ...

The unfolding and folding dynamics of TNfnALL probed by single molecule force–ramp spectroscopy

Tenascin, an important extracellular matrix protein, is subject to stretching force under physiological conditions and plays important roles in regulating the cell–matrix interactions. Using the recently developed single molecule force–ramp spectroscopy, we investigated the unfolding– folding kinetics of a recombinant tenascin fragment TNfnALL. Our results showed that all the 15 FnIII domains i...

Supramolecular Chemistry at the Single-Molecule LevelFinancial support from the Deutsche Forschungsgemeinschaft (SFB 613) is gratefully acknowledged.

In supramolecular chemistry synthetically designed organic constituents interact noncovalently, in a directed and specific way to form host–guest complexes of higher complexity. The ability to tailor the molecular interplay with respect of chemical design, specificity, and molecular switching opens up the development of new molecular materials for artificial molecular recognition, molecular org...